Chromosome 3: 133,463,679-133,545,139 reverse strand. Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor 1.14.11.- K24309 TET2_3; methylcytosine dioxygenase TET2… The TET2 gene is of particular importance for neoplastic evolution as it regulates the fate of hematopoietic stem and progenitor cells (HSCs) and is a founder lesion occurring early in the leukemic ontogenesis including its prominent role in clonal hematopoiesis of indeterminate potential (CHIP) as a precursor of myelodysplasia … Name Transcript ID bp Protein … In addition, other genes such as IDH1, IDH2, and c-CBL … Acquired inactivating mutations of the TET2 gene are frequently observed in human myeloid malignancies (i.e. protein-coding gene in the species Homo sapiens. The 'Meta-Gene' is an over-all accepted theory that Meta-Humans may inherit, or even gain, powers from alterations to a unique gene, which also explains how powers may be passed down from parent to offspring. « hide 10 20 30 40 50 malannltai lnllallcsi pitasgiwla skpdnecvnl lrwpvvvlgv 60 70 80 90 100 lilvvsatgf igaykyketl lavylccmai liglllvvli fafvvtrpdg 110 120 130 140 150 syrvpgrgyk eyrlegfsnw lkenvvdskn wgrlraclad tnvcpklnqe 160 170 180 190 200 fitadqffss skitplqsgc … Description. Somatic mutations in the DNA methylation regulating gene tet-methylcytosine dioxygenase 2 ( TET2 … Show transcript table Hide transcript table. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. These changes, which are called somatic mutations, are not inherited. TET2_ENST00000413648 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, TET2_ENST00000413648 Genome Browser, TET2_ENST00000413648 References TET2_ENST00000413648 - Explore an overview of TET2_ENST00000413648, with a histogram displaying coding … TET2 gene. Wiki-Pi: a web resource for human protein-protein interactions. wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound ... Tet2 - tet methylcytosine dioxygenase 2. PII: S0301-472X(17)30716-6 All structured data from the main, Property, Lexeme, and EntitySchema namespaces is available under the Creative Commons CC0 License; text in the other namespaces is available under the Creative Commons Attribution … Transcripts. This gene is involved in oxidation. Disease ID Disease name Source of annotation with TET2 OMIM link Number of associated genes genes; 614286: MYELODYSPLASTIC SYNDROME: OMIM: link to OMIM : 5: SETBP1, SF3B1, GATA2, TET2, ASXL1: My Genes; Showing 25 of 3,210 Results for TET2 Search Time: 0 ms. XB-GENEPAGE-6031109 Gene Symbol: tet2. Table 1. Skip to search form Skip to main content > Semantic Scholar's Logo. Somatic mutations in the TET2 gene have been identified in a small number of people with essential thrombocythemia, which is a condition characterized by high … may be involved in the regulation of cell differentiation. You are currently offline. In the red font, we depicted genes that, when upregulated, would reduce TET2 activity, while, with green, we depicted genes that, when downregulated, would reduce TET2 activity. Title: Tet2 restrains inflammatory gene expression in macrophages Author: Alyssa H. Cull, Brooke Snetsinger, Rena Buckstein, Richard A. Gene table of TET2 : tet methylcytosine dioxygenase 2 Gene-disease associations table . An exception to this rule is BRAF , in which case we discussed the V600F mutation and not an expression alteration. TET2 Gene. Some features of the site may not work correctly. We investigated ten–eleven translocation 2 (TET2) mutations in acute myeloid leukemia (AML), their correlation with other gene mutations and prognostic value. tet methylcytosine dioxygenase 2. TET2 (Tet Methylcytosine Dioxygenase 2) is a Protein Coding gene. View them in COSMIC-3D. Mus musculus. TET2 has not been detected as a mutational cancer driver in Bladder cancer. CCDS47120: D6RE87 E7EPB1 Q6N021: The GENCODE set is the gene set for human and mouse. Recent studies indicated that TET2 (TET gene family 2) plays an important role in DNA demethylation, the epigenetic regulation and normal hematopoiesis. Some gene mutations are acquired during a person's lifetime and are present only in certain cells. TET2 mutations in BCR-ABL1-negative myeloproliferative neoplasms. tet methylcytosine dioxygenase 2. Ensembl ID: ENSCAFG00000010876: Name: TET2: Description It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO … This page was last edited on 19 March 2021, at 04:42. Diseases associated with TET2 include Immunodeficiency 75 and Refractory Anemia.Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin Regulation / Acetylation. K24309 TET2_3; methylcytosine dioxygenase TET2/3 Enzymes [BR:ko01000] 1. Gene Name: tet methylcytosine dioxygenase 2 ... Gene Symbol: tet2. TET2 mutation has been discovered in a spectrum of myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and leukemia, which suggest the role of TET2 … TET2 mutations are found in subsets of all subtypes of MPN ().Inherited TET2 … This gene has 10 transcripts (splice variants) and 1 orthologue. The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. COSMIC gene TET2 (COSG540549) Genomic coordinates 4:105146293..105279816 (positive strand) Synonyms FLJ20032, KIAA1546, CCDS47120.1, Q6N021, ENSG00000168769.13 COSMIC-3D. Alternate Names: 54790 TET METHYLCYTOSINE DIOXYGENASE 2 TET2 KIAA1546 MDS 612839 25941 ENSG00000168769 OTTHUMG00000131213 Q6N021 PA162405634 FLJ20032 Gene Info: Gene Biotype: PROTEIN_CODING: Our goals are to offer a reliable up-to-date resource on the genes, their functions, alternative variants, expression, regulation and … AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on the genome sequence.
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